An Overview of Natural and Synthetic Coumarin Derivatives as Potential Antidiabetic Agents

The common term for cis-o-hydroxy cinnamic acid lactones, which all possess the fundamental structure of benzo a-pyranone mother nucleus, iscoumarins. Especially in Umbelliferae, Rutaceae, Daphne, and Oleaceae, coumarins are extensively dispersed roots, stems, leaves, flowers, fruits,and seeds higher plants. A few also detected certain microbes mammals. Certain coumarin molecules may be synthesizedartificially. We have discussed probable mechanisms behind coumarins' anti-diabetic benefits. Numerous vivo vitro studies show thatcoumarins treat diabetes by reducing inflammation oxidative stress, enhancing pancreatic function, reversing aberrant insulin signaling.As a result, they useful need further study development. In conclusion, it is clear that range biochemical andpharmacological characteristics, some potential therapeutic value against its consequences. To sum up,improvements area allowed isolation or chemical design novel advantageous compounds with cores as candidates againstdiabetes consequences; nevertheless, additional necessary before safe effective medications employed clinic.